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The series also features numerous supporting characters, each of whom plays a prominent role in a small group of episodes.
Included among them are parents of the main characters, their dates and their coworkers.
Beverly Hofstadter, is a neuroscientist and world-renowned psychiatrist, his sister is a medical researcher, and his father, Dr. Also, his brother Michael is a Harvard law professor.
In season five's "The Recombination Hypothesis", Leonard and Penny start dating anew, and although their relationship is initially rocky and Penny has doubts, in season six, she works through her doubts and has a stronger relationship with Leonard.
In season six's "The 43 Peculiarity", she tells him she loves him for the first time, and this now makes them more comfortable in their relationship.
Originally from New Jersey, he received his Ph D at age 24, spending at least some of his time at Princeton University.
He shared an apartment in Pasadena with colleague and friend Dr. Unlike his equally geeky friends, Leonard is interested and quite adept in building interpersonal and social relationships with other people.
Following his break-up with Penny, Leonard began a relationship with Raj's sister Priya in season four, and it is implied they had a brief sexual encounter before the start of the series.